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BUTHIONINE SULFOXIMINE
Descriptors Found:
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DeCS
Descriptor
English
:
Buthionine Sulfoximine
Descriptor
Spanish
:
Butionina Sulfoximina
Descriptor
Portuguese
:
Butionina Sulfoximina
Synonyms
English
:
Sulfoximine, Buthionine
Tree Number:
D02.886.030.676.620.125
D12.125.166.676.620.125
Definition
English
:
A synthetic amino acid that depletes
glutathione
by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in
glutathione
biosynthesis. It has been shown to inhibit the proliferative response in human
T-lymphocytes
and inhibit
macrophage activation
. (J Biol Chem 1995;270(33):1945-7)
Pharmacological Action:
Antimetabolites
Antimetabolites, Antineoplastic
Enzyme Inhibitors
Radiation-Protective Agents
Radiation-Sensitizing Agents
History Note
English
:
97: was BUTHIONINE SULFOXIMINE (NM) 1979-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33034
Unique Identifier:
D019328
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
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